Optim Equine The Risks of Altrenogest (AKA: Regumate/Readyserve/Ovamed/Altren) to Humans

The Risks of Altrenogest (AKA: Regumate/Readyserve/Ovamed/Altren) to Humans

Mares and fillies who exhibit overtly hormonal behaviour can be a real challenge and frustration for riders, trainers and owners. In an attempt to help manage their behaviour, many of these mares and fillies are given the drug altrenogest.

Altrenogest, commonly referred to as Regumate or Readyserve (two of its trade names) is a synthetic progesterone product used to suppress oestrus in mares (and often used to help ‘maintain’ pregnancy in ‘problem’ pregnancy mares). It is the first choice by many horse people to help ‘control their marey-mare’.

Whilst the health issues associated with the use of altrenogest in horses are extensive, it’s well worth being aware of health implications in humans.

Scarily, altrenogest is routinely viewed and handled as a relatively harmless substance. Yet this drug can cause significant hormonal and health problems to humans who come into contact with it. Altrenogest has been widely reported to the Food and Drug Administration (FDA) for its adverse effects in both men and women.  Exposure is most commonly reported following drug contact with the skin, but it is important to note that some reported exposures occur in conjunction with touching product residue on barn surfaces, equipment, and treated animals. Put simply, you don’t even directly have to handle the drug to suffer adverse health effects from it.

The most significant noted health implications of human exposure to altrenogest involve reproductive system issues, including abnormal menstrual cycles in women (changes in bleeding frequency, pattern and amount). Girls as young as 14 years old have been effected- an alarming consequence. In men, decreased libido has been reported. Headaches, fever, abdominal pain, nausea, diarrhoea, vomiting and skin rashes have also been associated with exposure to altrenogest.

The labelling for all altrenogest products include warnings against human exposure as the hormone is readily absorbed through intact skin. It’s easy to think that wearing latex gloves will protect us from the harmful effects of this medication. But this is a misconception: latex allows the passage of altrenogest through it, which can then penetrate the skin. Once altrenogest has been spilt on the gloves and soaked through, it is then more readily absorbed by the skin compared to being able to pass back through the glove. Essentially this practice creates an ‘altrenogest patch’.

When it comes to the use of altrenogest in fillies and mares, it is important to remember that the causes of hormonal problems and imbalances may be due to many factors. Feeding practices, nutritional status, inflammation, body composition, gastrointestinal health and stress levels are all very important, yet are commonly overlooked. Appropriately prescribed herbal medicines and nutritional supplements, alongside sound dietary and management practices can significantly help the ‘hormonal’ mare or filly. Understanding why a mare or filly exhibits such behaviour is really important to promote overall best health and performance. Simply manipulating hormone levels through the addition of synthetic progesterone rarely helps to address the cause: it simply bandaids it.

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